Abstract
Extract: Kidneys from 14 children with diagnosis of recurrent pyelonephritis were studied for deposits of Escherichia coli, antigen, complement component C3, and immunoglobulincontaining cells using immunofluorescence.
E. coli O antigen was found in a scarred region in the kidney from only one patient. This was also confirmed by indirect hemagglutination inhibition using eluted antigen from the kidney.
In 10 of the 14 patients immunoglobulin G- as well as A-containing plasma cells were seen, while immunoglobulin M-containing cells were found in 6 kidneys. No deposits of complement were observed in any of the kidneys.
Speculation: The deposition of E. coli antigen in kidneys after pyelonephritis might be of significance for the development of kidney scarring.
Local antibody synthesis in the infected kidney might occur as a protection against the invading organisms.
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Kaijser, B., Hagberg, S., Hanson, L. et al. A Search for Escherichia coli Antigens in Kidneys from Children with Urinary Tract Infection by Means of Immunofluorescence. Pediatr Res 8, 935–940 (1974). https://doi.org/10.1203/00006450-197412000-00004
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DOI: https://doi.org/10.1203/00006450-197412000-00004
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