Abstract
8 breast-fed and 9 bottle-fed infants were colonized after birth with a non-enteropathogenic E.coli strain. 11 breast-fed and 10 bottle-fed infants were used as controls. In colonized infants the strain 083 was detected in the stool from the 2nd day and remained in predominance up to 16 weeks. The serum antibody against E. coli 083 increased between 4-16 weeks. The colonization did not influence significantly the serum immunoglobulin levels. In colonized bottle-fed infants the level of copro-antibodies was significantly higher from 4 up to 16 weeks than in controls, in breast-fed colonized infants between 2-6 weeks. The colonization induced a formation of secretory IgA in bottle-fed infants from the 4th up to the 16th week. In breast-fed infants this effect was masked due to passive transfer of IgA via maternal milk. In 24 cases of diarrhoea caused by E. coli an antibody against E.coli 055, 0111 and 026 was administered orally 7 times, 2ml/kg. In 19 infants the stools turned to normal.
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Lodinová, R., Jouja, V. The immunoglobulins and coproantibody formation in infants after artificial intestinal colonization with E. coli 083. Protective effect of orally administered antibody. Pediatr Res 8, 910 (1974). https://doi.org/10.1203/00006450-197411000-00074
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DOI: https://doi.org/10.1203/00006450-197411000-00074