Abstract
An 8 months old male child affected with acrodermatitis enteropathica was treated intravenously with the dialysate of an enzymatic hydrolysate of casein for three periods of 7-10 days each. This treatment consistently resulted in dramatic improvement of the child's general condition with complete healing of the skin lesions. The disease relapsed whenever the protein hydrolysate was discontinued. When the hydrolysate was replaced by mixtures of essential aminoacids no improvement was noted, even when all nine essential aminoacids (including histidine) were administered. Available evidence indicates that protein hydrolysates contain factor(s) that are effective in the treatment of acrodermatitis enteropathica. It is also suggested that this disease is not due to malabsorption of essential aminoacids through the intestine.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Der Kaloustian, V., Wakid, N. & Murib, A. The effect of intravenous administration of aminoacids in acrodermatitis enteropathica. Pediatr Res 8, 909 (1974). https://doi.org/10.1203/00006450-197411000-00072
Issue Date:
DOI: https://doi.org/10.1203/00006450-197411000-00072