Abstract
Various complement components are estimated in the sera of patients with renal disease for the purposes of diagnosis and investigation. Deviation from normality may reflect involvement in the pathogenetic process, or may be a secondary consequence of proteinuria. We have therefore systematically measured plasma Clq, C4, C3, GBG, lgG (and specifically subclass 3), lgA and lgM, and have related them to the plasma concentration of albumin and to the urine albumin/creatinine concentration ratio.
GBG correlates positively with the plasma albumin concentration, and negatively with the urine albumin/creatinine ratio, indicating that its serum concentration is affected by urinary loss. Plasma lgG, but not lgG subclass 3, correlates positively with plasma albumin, indicating a different clearance and/or turnover rate of lgG3 from other IgG subclasses.
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Anttila, R., Barratt, T. & Soothill, J. The concentrations of immunoglobulins and complement components in the sera of children with glomerular disease. Pediatr Res 8, 901 (1974). https://doi.org/10.1203/00006450-197411000-00040
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DOI: https://doi.org/10.1203/00006450-197411000-00040