Abstract
Recent studies by Anast et al (Science 117-606 1972) and by Sun et al (J.Clin.Invest. 52-153 1973) have shown that severe magnesium deficiency induces inpired parathyroid function and that this impairment is responsible at least in part for the secondary hypocalemia However it is not known if the synthesis or the release of PTH or both, are affected in this syndrome. The present study was undertaken to investigate the type of impairment of the parathyroid function during hypomagnesemia.
The clinical course of the 5 years old boy in whom the present investigations were carried out have been reported previously (Pouillaude et al. Arch.Franc.Ped.28-1021-1971). During the hypocalcemic and hypomagnesemic state we confirmed that the bone system and the kidneys were responsive to exogenous bovine PTH as demonstrated by the normalisation of the calcemia and the increase of urinary hydroiyproline and c AMP. Low to non detectable levels of serum immunoreactive PTH gived also clear indication of impaired parathyroid function. By contrast IV injection of S04 Mg induced an instantaneous and sharp increase of serum IPTH as shown by levels above the normal range 10 mn after the injection. This was followed by a regular decrease of IPTH level reaching the normal range 2 hours later. Me believe that this finding favors the view that magnesium depletion induce impaired FTH-release in man.
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David, L., Chappuis, M. & Francois, R. Further studies on the pathogenesis of hypocalcemia in primary hypomagnesemia. Evidence for a defect in the relase process of parathyroid hormone (PTH). Pediatr Res 8, 898 (1974). https://doi.org/10.1203/00006450-197411000-00027
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DOI: https://doi.org/10.1203/00006450-197411000-00027