Abstract
Extract: The pancreatic secretion rates of fluid, protein, Na+, K+, Ca++, and HCO3- before and after pancreozymin and secretin stimulations have been studied in 25 premature and 12 full term newborn infants. The secretion rates are (with few exceptions) higher in premature than in full term newborn infants. In both groups of subjects at birth the pancreozymin and the secretin stimulations yield an increment of pancreatic secretion rates; differences between the responses to pancreozymin and secretin have been observed but are statistically not significant; a statistically significant differentiated response to each of the two hormones appeared only in premature newborn infants at 1 month of age.
Speculation: In premature and full term newborn infants the exocrine pancreas is functionally unable to distinguish pancreozymin from secretin at birth, but it is able to do so at 1 week of age. A week of adaptation to extrauterine life seems to be necessary in order to obtain a response to hormonal stimulation qualitatively similar to, although quantitatively lower than, that of older infants and children.
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Zoppi, G., Andreotti, G., Pajno-Ferrara, F. et al. The Development of Specific Responses of the Exocrine Pancreas to Pancreozymin and Secretin Stimulation in Newborn Infants. Pediatr Res 7, 198–203 (1973). https://doi.org/10.1203/00006450-197304000-00023
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DOI: https://doi.org/10.1203/00006450-197304000-00023
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