Abstract
Extract: The activities of the first two enzymes of the de novo pyrimidine biosynthetic pathway, carbamyl phosphate synthetase (GPS) and aspartate transcarbamylase (ATG) (EG. 2.1.3.2), were closely correlated with cellular proliferation in rat cerebellum. Uridine kinase demonstrated a different developmental pattern which suggests an important role, in nondividing cells, for the pathway by which preformed pyrimidines are utilized for nucleic acid synthesis.
Speculation: De novo synthesis provides the major source of pyrimidine nucleotides required for nucleic acid synthesis in developing rat brain. Mature brain obtains its pyrimidine nucleotides for nucleic acid synthesis primarily from utilization of bases and nucleosides released from the breakdown of preexisting nucleic acid.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Weichsel, M., Hoogenraad, N., Levine, R. et al. Pyrimidine Biosynthesis during Development of Rat Cerebellum. Pediatr Res 6, 682–686 (1972). https://doi.org/10.1203/00006450-197208000-00006
Issue Date:
DOI: https://doi.org/10.1203/00006450-197208000-00006