Abstract
Extract: We have found a genetic trait of arginase deficiency in erythrocytes (RBC) of Macaca fascicularis (crabeater macaque). Measurements of arginase activities and arginine concentrations in RBC, and information derived from breeding experiments indicated that arginase activities in RBC are 12.59 mmoles/g hemoglobin (Hb)/hr (range: 8.36–15.24) in normal monkeys, 4.40 mmoles/g Hb/hr (sd ± 2.37) in hetero-zygotes for this trait, and less than 0.05 mmoles/g Hb/hr in homozygotes for this trait. Concentrations of arginine in erythrocytes are less than 0.01 $mUmoles/ml packed cells in both normal and heterozygous monkeys, and 0.975 $mUmoles/ml packed cells (sd ± 0.556) in homozygous monkeys.
There are no significant differences in plasma amino acids and hepatic arginase activity in any animal.
Speculation: Study of arginase activity in RBC will be expanded to include a large number of monkeys in order to determine the incidence of arginase deficiency in RBC in this species. The possibility of using these monkeys as an animal model for study of human disease arginase deficiency (e.g., genetic engineering) will be explored.
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Shih, V., Jones, T., Levy, H. et al. Arginase Deficiency in Macaca fascicularis. I. Arginase Activity and Arginine Concentration in Erythrocytes and in Liver. Pediatr Res 6, 548–551 (1972). https://doi.org/10.1203/00006450-197206000-00003
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DOI: https://doi.org/10.1203/00006450-197206000-00003
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