Abstract
Data were obtained on the influence of vincristine (7 × 10−5M) on the in vitro incorporation of both 6-11C-orotate into RNA and of 1-14C leucine into proteins of leucine cells from acute lymphocytic leukemia. Orotate and leucine incorporation were measured after 2 and 12hr of incubation. A total of 17 patients were examined. Most of the in vitro studies were conducted on peripheral blast cells. In 4 instances also bone marrow leukemic cells were tested. In any case in which a good clinical response by vincristine administration was recorded, also a strong in vitro inhibition of both RNA and protein synthesis was odserved. On the contrary, in the only 2 cases in which a definitive in vivo resistance to vincristine was observed, also an in vitro lack of response was found. Practical implications of these studies will be discussed.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sereni, L., Masira, G., Carnella, V. et al. 66. In vitro sensitivity to vincristine of acute lymphocylic leukemia Cells—a tentative to corrnelate in vivo and in vitro results. Pediatr Res 5, 97 (1971). https://doi.org/10.1203/00006450-197102000-00071
Issue Date:
DOI: https://doi.org/10.1203/00006450-197102000-00071