Abstract
Active immunotherapy, used alone, is unlikely to be of value in cases of advanced maliganant disease. There is evidence, however, that it may be useful in eliminating small number of tumour cells remaining after other forms of treatment. It was decided to test this proposal in chemically induced fibrosarcomas in mice. Various forms of active immunotherapy were tested. Nonspecific stimulation of the immune response with Corynebacterium parvum gave the most promising results. This was then combined in various regimens with chemotherapy0. Combining cyclophosphamide with subsequent C. parvum, 12 days later, produced a significant number of complete and lasting regressions. The results are discussed with reference to the use of nonspecific stimulants of the immune response in man.
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Gurpie, G. 28. Active immunotherapy as an adjunct to chemotherapy in the control of solid tumours. Pediatr Res 5, 89 (1971). https://doi.org/10.1203/00006450-197102000-00033
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DOI: https://doi.org/10.1203/00006450-197102000-00033