Abstract
Extract: Sodium content and various components of sodium outflux were measured in erythro-cytes from 26 normal subjects, 25 patients with cystic fibrosis of the pancreas (CFP), and 20 parents of patients with CFP.
Ouabain-insensitive, ethacrynic acid-sensitive fractional sodium outflux was diminished in erythrocytes from males with CFP (0.027 versus 0.051 for normal males) and from postpubertal females with CFP (0.012 versus 0.023 for normal adult females). This same component was normal in erythrocytes from prepubertal females with CFP (0.052 versus 0.046 for normal prepubertal females). Fractional sodium outflux in erythrocytes from obligate heterozygotes of either sex did not differ significantly from that of their normal counterparts.
Speculation: None of the components of sodium outflux reported here can be used as a genetic marker for CFP. The abnormalities of sodium outflux in patients with CFP are not related directly to the basic defect but instead represent a secondary feature of the disease.
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Lapey, A., Gardner, J. Abnormal Erythrocyte Sodium Transport in Cystic Fibrosis of the Pancreas. Pediatr Res 5, 446–451 (1971). https://doi.org/10.1203/00006450-197109000-00002
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DOI: https://doi.org/10.1203/00006450-197109000-00002
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