Abstract
Combined lyophilized Moraten measles, Jeryl Lynn mumps, and HPV 77 duck rubella vaccines were administered by a single injection to 715 children ages 7 months to 7 years, and susceptible to these viruses. The geometric mean antibody responses to the triple vaccine were comparable to those obtained with monovalent vaccines. The antibody seroconversion rate was 96% to measles by hemagglutination-inhibition tests, 95% to mumps neutralization tests and 94% to rubella hemagglutination-inhibition tests. Clinical reactions to the triple vaccine were no greater than those following measles vaccine given alone. Arthralgia and arthritis were not reported during the 28 day recording period. In children combined measles-mumps-rubella vaccine provides a sofe, simple and economical means of immunizing against these three diseases. Similar findings were obtained in tests in 375 seronegative children given combined measles-rubella vaccine and in 415 seronegative children given combined mumps-rubella vaccine.
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Weibel, R., Stokes, J., Villarejos, V. et al. Studies of immunization with three types of combined viral vaccines. Pediatr Res 5, 402 (1971). https://doi.org/10.1203/00006450-197108000-00130
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DOI: https://doi.org/10.1203/00006450-197108000-00130