Abstract
Speculation: Two important predictions, contradicting current opinion, arise from his review:
Removal of the pituitary causes loss of muscle deoxyribonucleic acid (DNA) in the weanling rat. Exercise causes increase in muscle tissue with a commensurate increase in DNA and protein. Therefore, some of the muscle DNA must be in a dynamic state.
Calorie restriction (without protein restriction) imposed during the postweanling period of growth in rats does slow cell multiplication but does not cause permanent growth retardation. Therefore, protein restriction, per se, is probably responsible for permanent growth retardation in the experimental animal.
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Cheek, D., Holt, A., Hill, D. et al. Skeletal Muscle Cell Mass and Growth: The Concept of the Deoxyribonucleic Acid Unit. Pediatr Res 5, 312–328 (1971). https://doi.org/10.1203/00006450-197107000-00004
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DOI: https://doi.org/10.1203/00006450-197107000-00004
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