Abstract
Renal clearances of 3 plasma proteins were studied in the mature and immature human neonate and adut to test the hypothesis that capillary permeability may be directly related to immaturity in the human, as it is in the sheep [J. Physiol. 201: 567, 1969] and dog [Amer.J. Physiol. 213: 441, 1967]. Urine was collected for 18-24 h, filtered, dialzyed and concentrated by lyophilization. Protein concentrations were measured in the serum and concentrated urine by the technique of radial immunodiffusion with specific antisera. Eighty to 90% of the 3 proteins studied were recovered from pooled human serum diluted to the approximate protein concentration of urine and subjected to the same procedureds. Clearances (mean±SD) × 10−2 in ml/kg body wt/24 h and the number of subjects studies (in parentheses) follow:
Thus, there was 1.5- to 7-fold greater clearance for full-term infants than for adults and 5- to 7-fold greater clearance for premature than for full-term infants. Protein clearances did not correlate with molecular weights.
The data suggest that the immature as compared to the mature human has greater glomerular capillary permeability, greater tubular excretion or decreased tubular reabsorption either singly or in combination.
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Morphis, L., Taylor, P. & Fireman, P. Immaturity and Enhanced Renal Clearances of Native Proteins. Pediatr Res 4, 446 (1970). https://doi.org/10.1203/00006450-197009000-00049
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DOI: https://doi.org/10.1203/00006450-197009000-00049