Abstract
Extract: The production of IgG, IgA, IgM, β1c, and the secretory piece (SP) by the cells of human colostrum was investigated by radioimmunoelectrophoresis. The synthesis of IgA and β1c by the cells was demonstrated. No evidence, however, for the formation of IgG of IgM by colostral cells was found. Similarly, no radiolabeling was found over the free SP immunoprecipitin lines, but labeling was detected over the bound SP immunoprecipitin lines. This many have been due to covalent binding of the SP with radiolabeled α chains of secretory IgA.
Speculation: IgA produced by the cells of human colostrum may be used in the formation of secretory IgA and may be an important source of antibodies in colostrum.
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Murillo, G., Goldman, A. The Cells of Human Colostrum II. Synthesis of IgA and β1c. Pediatr Res 4, 71–75 (1970). https://doi.org/10.1203/00006450-197001000-00008
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DOI: https://doi.org/10.1203/00006450-197001000-00008
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