Abstract
Reports based on adult patients suggest that either GFR or RPF can be measured accurately from the rate of disappearance of a radionuclide from the blood following a single intravenous injection. Although the advantage of avoiding urine collections in children is obvious, few attempts have been made to validate the method in this age group. Inulin, creatinine, and PAH clearances were performed and compared with simulataneous measurements obtained from iothalamate 125I or orthoiodohippurate 131I disappearance curves calculated as clearances by compartmental analysis (open, two compartment system). The results obtained in 31 patients ranging in age from 18 months to 16 years, with levels of renal function as estimated by CIN between 20 an d 158ml/min/1.73 m2, were:
No differences attributable to age or level of function were observed. It appears, therefore, that GFR or RPF can be estimated validly in children using the disappearance of a radionuclide from the blood.
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Silkalns, G., Jeck, D., Spitzer, A. et al. Measurement of Renal Function by Radionuclide Disappearance Curves. Pediatr Res 4, 450 (1970). https://doi.org/10.1203/00006450-197009000-00065
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DOI: https://doi.org/10.1203/00006450-197009000-00065