Abstract
Extract: A newly developed inactivated, alum-adsorbed parainfluenza vaccine was evaluated for its effectiveness in evoking antibody responses in young infants. Immunization consisted of three monthly doses of 0.5 ml each. Four age groups were selected for initiation of immunization; 2 days, 6 weeks, 12 weeks and 24 weeks of age.
Successful immunization was achieved when immunization was begun at 24 weeks of age (7 of 8 infants with 4-16 fold increase in antibody titer). Younger infants were successfully immunized if the pre-immunization serum antibody titer was less than 1 : 64 (12/15 [80 %] infants with pre-immunization titers of 1 : 32 or less developed 4-32 fold increase in antibody titer) (fig. 6).
Maternal antibody may interfere with immunization with parainfluenza vaccine in infants below the age of 6 months. Some infants, regardless of age, are successfully immunized if the titer of maternal antibody is sufficiently low.
Speculation: It is possible that, using a sufficiently potent antigen, parainfluenza virus immunization may be successful regardless of age.
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Fulginti, V., Sieber, O., John, T. et al. Parainfluenza Virus Immunization: II. The Influence of Age and Maternal Antibody upon Successful Immunization with an Alum-Adsorbed Parainfluenza Type 3 Vaccine. Pediatr Res 1, 50–58 (1967). https://doi.org/10.1203/00006450-196701000-00006
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DOI: https://doi.org/10.1203/00006450-196701000-00006