Abstract
Assessment was made of the feasibility of forming hydroxyapatite on/in naturally occurring swollen biodegradable chitosan hydrogels through an alternate soaking process. This study focused on the effects of crosslinking and swelling on hydroxyapatite formation. Two chitosan solutions (1.75 wt% and 1.5 wt%) were prepared at various glutaraldehyde (GA) feed to obtain appropriate network structures. The amount of hydroxyapatite formed increased with swelling and decrease in crosslinking density. The hydrogel prepared from the 1.75 wt% chitosan solution showed more hydroxyapatite formed on/in the swollen chitosan hydrogel matrix than the 1.5 wt% chitosan solution hydrogel at the same GA feed and/or swelling. The swelling of the chitosan-hydroxyapatite composites was smaller than that of the chitosan hydrogel. The three-dimensional structure of the hydroxyapatite composite could be controlled by manipulating certain parameters of the starting chitosan hydrogel.
Similar content being viewed by others
Article PDF
References
L. Cleries, J. M. Fernandez-Pradas, and J. L. Morenza, J. Biomed. Mater. Res., 49, 43 (2000).
A. P. Valagao, A. do Serro, A. C. Fernandes, and B. J. V. Saramago, J. Biomed. Mater. Res., 49, 345 (2000).
B. C. Yang, J. Weng, and X. D. Zhang, J. Biomed. Mater. Res., 47, 213 (1999).
H. Zeng and W. R. Lacefield, Biomaterials, 21, 23 (2000).
J. D. Haman, K. K. Chittur, D. E. Crawmer, and L. C. Lucas, J. Biomed. Mater. Res., 48, 856 (1999).
B. J. Story, A. V. Burgess, D. La, and W. R. Wagner, J. Biomed. Mater. Res., 48, 841 (1999).
Z. E. Erkmen, J. Biomed. Mater. Res., 48, 861 (1999).
H. Morgan, R. M. Wilson, J. C. Elliott, S. E. P. Dowker, and P. Anderson, Biomaterials, 21, 617 (2000).
I. Izquierdo-Barba, A. J. Salinas, and M. Vallet-Regi, J. Biomed. Mater. Res., 47, 243 (1999).
T. Kokubo, J. Non-Cryst. Solids, 120, 138 (1990).
G. J. Liu, F. Miyaji, T. Kokubo, H. Takadama, T. Nakamura, and A. Murakami, J. Mater. Sci.: Mater. Med., 9, 285 (1998).
T. Taguchi, A. Kishida, and M. Akashi, Chem. Lett., 711 (1998).
T. Taguchi, A. Kishida, and M. Akashi, J. Biomater. Sci., Polym. Ed., 10, 331 (1999).
T. Taguchi, A. Kishida, and M. Akashi, J. Biomater. Sci., Polym. Ed., 10, 795 (1999).
T. Taguchi, M. Shiraogawa, A. Kishida, and M. Akashi, J. Biomater. Sci., Polym. Ed., 10, 19 (1999).
T. Taguchi, Y. Muraoka, H. Matsuyama, A. Kishida, and M. Akashi, Biomaterials, 22, 53 (2001).
Q. Li, E. W. Grandmaison, and M. F. A. Goosen, in “Applications of Chitin and Chitosan”, M. F. A. Goosen, Ed., Technomic Publishing Company, Inc., Lancaster, 1997, chapter 1.
R. A. A. Muzzarelli, in “Chitin”, Pergamon Press, Oxford, 1997, pp 134–137.
H. Aoki, in “Medical Applications of Hydroxyapatite”, Ishiyaku EuroAmerica, Inc., Tokyo, 1994, chapter 8, p 176.
L. Noble, A. I. Gray, L. Sadiq, and I. F. Uchegbu, Int. J. Pharm., 192, 173 (1999).
M. Kawase, N. Michibayashi, Y. Nakashima, N. Kurikawa, K. Yagi, and T. Mizoguchi, Biol. Pharm. Bull., 20, 708 (1997).
Y. Ohya, T. Takei, H. Kobayashi, and T. Ouchi, J. Microencapsulation, 10, 1 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tachaboonyakiat, W., Serizawa, T. & Akashi, M. Hydroxyapatite Formation on/in Biodegradable Chitosan Hydrogels by an Alternate Soaking Process. Polym J 33, 177–181 (2001). https://doi.org/10.1295/polymj.33.177
Issue Date:
DOI: https://doi.org/10.1295/polymj.33.177
Keywords
This article is cited by
-
Fabrication and Characterization of Gelatin/Calcium Phosphate Electrospun Composite Scaffold for Bone Tissue Engineering
Fibers and Polymers (2022)
-
Synthesis and characterization of chitosan–multiwalled carbon nanotubes/hydroxyapatite nanocomposites for bone tissue engineering
Journal of Materials Science: Materials in Medicine (2013)
-
Calcium orthophosphate-based biocomposites and hybrid biomaterials
Journal of Materials Science (2009)