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Recruitment strategies and comparison of prostate cancer-specific clinical data on African-American and Caucasian males with and without family history

Prostate Cancer and Prostatic Diseases volume 11, pages 274–279 (2008)Cite this article

Abstract

Prostate cancer is the most common cancer in men in the United States. This is a complex disease with high heterogeneity and the exact causes are unknown in population-specific samples. Family history is a primary risk factor irrespective of race. Identifying prostate cancer families with multiple affected cancer cases is challenging. Herein we document recruitment techniques and present prostate cancer clinical factors described in a cohort of African Americans and Caucasians with or without a strong family history. A total of 521 prostate cancer patients (241 African Americans and 280 Caucasians) were identified using a novel cooperative methodology involving a combination of treating physicians and tumor registries. Higher prostate-specific antigen (PSA, P=0.0269) was found in familial cases as compared to sporadic cases in African-American men. In addition, PSA values for familial cases were higher (P=0.0093) in African-American as compared to Caucasian men. No differences were detected in Gleason score values in either race, regardless of family history. These findings remained the same after adjustment was made for age at diagnosis. In conclusion, methodologies for cohort acquisition, and clinical characteristics, are described for men with and without a family history of prostate cancer using both Caucasian and African-American populations.

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Acknowledgements

We thank the study participants. We also thank the collaborating hospitals and the physicians. We especially thank Josalin Hunter for her assistance in reviewing medical records and Leah Balhoff for her technical assistance. This research was funded in part by the Louisiana Board of Regents (LEQSF (2002-05)-RD-A-15), the NCI (1 RO3 CA97778-01), the Cancer Research Foundation of America, the Centers for Disease Control and Prevention (H57/CCH 624034-01), Louisiana Cancer Research Consortium and the institutional funding from the Louisiana State University School of Medicine.

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Author notes

  1. O Sartor

    Present address: 6Current address: Harvard and Dana-Farber Cancer Institute, MA, USA.,

  2. S L Halton

    Present address: 7Current address: Department of Neurology, Baylor College of Medicine, Houston, TX, USA.,

  3. W Rayford

    Present address: 8Current address: Southeast Urology Network, Memphis, TN, USA.,

Authors and Affiliations

  1. Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    D M Mandal & S L Halton

  2. Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    O Sartor

  3. Department of Biostatistics, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    D E Mercante

  4. National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA

    J E Bailey-Wilson

  5. Department of Urology, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    W Rayford

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  1. D M Mandal
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  2. O Sartor
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Correspondence to D M Mandal.

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The authors state there are no competing interests.

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Mandal, D., Sartor, O., Halton, S. et al. Recruitment strategies and comparison of prostate cancer-specific clinical data on African-American and Caucasian males with and without family history. Prostate Cancer Prostatic Dis 11, 274–279 (2008). https://doi.org/10.1038/pcan.2008.5

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