The first structures of an intramembrane serine protease reveal a catalytic His-Ser dyad in a water-filled cavity surrounded by six transmembrane helices, but just how substrate helices gain access to the dyad is controversial.
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Acknowledgements
This work was supported in part by grants from the National Institute of General Medical Sciences and the National Center for Research Resources, US National Institutes of Health.
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White, S. Rhomboid intramembrane protease structures galore!. Nat Struct Mol Biol 13, 1049–1051 (2006). https://doi.org/10.1038/nsmb1206-1049
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DOI: https://doi.org/10.1038/nsmb1206-1049
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