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A bacterial big-MAC attack

Nature Structural & Molecular Biology volume 11, pages 1163–1164 (2004)Cite this article

Certain pathogens and bacterial toxins exhibit exquisite host specificity, the determinants of which often remain mysterious. A recent report shows that the human specificity of the pore-forming toxin intermedilysin (ILY), a member of the cholesterol-dependent cytolysins (CDCs), is due to its specific interaction with the human cluster of differentiation protein CD59.

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Figure 1: PFT membrane association.

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Authors and Affiliations

  1. Department of Microbiology and Molecular Medicine, University of Geneva, 1 rue Michel Servet, Geneva, 1211 4, Switzerland

    Ioan Iacovache & F Gisou van der Goot

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  1. Ioan Iacovache
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  2. F Gisou van der Goot
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Iacovache, I., van der Goot, F. A bacterial big-MAC attack. Nat Struct Mol Biol 11, 1163–1164 (2004). https://doi.org/10.1038/nsmb1204-1163

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