Structural studies by the Ramakrishnan and Agris groups allow us to directly observe how the ribosome's decoding site accommodates non-Watson-Crick base pairs in the third position of the codon-anticodon triplet while maintaining the one-amino-acid-per-codon framework that is central to life.
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Cochella, L., Green, R. Wobble during decoding: more than third-position promiscuity. Nat Struct Mol Biol 11, 1160–1162 (2004). https://doi.org/10.1038/nsmb1204-1160
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DOI: https://doi.org/10.1038/nsmb1204-1160
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