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Multienzyme assembly of a p53 transcription complex

Nature Structural & Molecular Biology volume 14, pages 885–887 (2007)Cite this article

Proline isomerization of the p53 transactivation domain has a central role in coordinating kinase signaling pathways that assemble the core p53 transcription complex.

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Figure 1: Regulatory domains of p53 that modulate DNA-dependent acetylation.
Figure 2: Enzymatic stages in the assembly of the acetylated p53 transcription complex.
Figure 3: Models for regulation by PIN.

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Authors and Affiliations

  1. Ted R. Hupp is at the Institute of Genetics and Molecular Medicine, Cancer Research UK p53 Signal Transduction Group, and Malcolm Walkinshaw is at the Institute for Translational and Chemical Biology, The University of Edinburgh, Edinburgh, EH4 2XR, UK. ted.hupp@ed.ac.uk or malcolm.walkinshaw@ed.ac.uk,

    Ted R Hupp & Malcolm Walkinshaw

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  1. Ted R Hupp
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  2. Malcolm Walkinshaw
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Hupp, T., Walkinshaw, M. Multienzyme assembly of a p53 transcription complex. Nat Struct Mol Biol 14, 885–887 (2007). https://doi.org/10.1038/nsmb1007-885

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