Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Out of hot water

Nature Structural & Molecular Biology volume 11, pages 912–913 (2004)Cite this article

A recent study of adenylate kinase reveals that conformational dynamics in control product release and determine the rate-limiting step in the overall catalytic reaction.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Hammes-Schiffer, S. Biochemistry 41, 13335–13343 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Benkovic, S.J. & Hammes-Schiffer, S. Science 301, 1196–1202 (2003).

    Article  CAS  PubMed  Google Scholar 

  3. Wolf-Watz, M., Thai, V., Henzler-Wildman, K., Hadjipaylou, G., Eisenmesser, E.Z. & Kern, D. Nat. Struct. Mol. Biol. 11, 945–949 (2004).

    Article  CAS  PubMed  Google Scholar 

  4. Jaenicke, R. & Böhm, G. Curr. Opin. Struct. Biol. 8, 738–748 (1998).

    Article  CAS  PubMed  Google Scholar 

  5. Fersht, A. Structure and mechanism in protein science. A guide to enzyme catalysis and protein folding, 631 (W.H. Freeman & Co., New York, 1999).

    Google Scholar 

  6. Bruice, T.C. & Benkovic, S.J. Biochemistry 39, 6267–6274 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Warshel, A. Acc. Chem. Res. 35, 385–395 (2002).

    Article  CAS  PubMed  Google Scholar 

  8. Garcia-Viloca, M., Gao, J., Karplus, M. & Truhlar, D.G. Science 303, 186–196 (2004).

    Article  CAS  PubMed  Google Scholar 

  9. Szilagyi, A. & Zavodszky, P. Structure 8, 493–504 (2000).

    Article  CAS  PubMed  Google Scholar 

  10. Jaenicke, R. Proc. Natl. Acad. Sci. USA 97, 2962–2964 (2000).

    Article  CAS  PubMed  Google Scholar 

  11. Vieille, C. & Zeikus, G.J. Microbiol. Mol. Biol. Rev. 65, 1–43 (2001).

    Article  CAS  PubMed  Google Scholar 

  12. Somero, G.N. Annu. Rev. Ecol. Syst. 9, 1–29 (1978).

    Article  CAS  Google Scholar 

  13. Zavodszky, P., Kardos, J., Svingor, A. & Petsko, G.A. Proc. Natl. Acad. Sci. USA 95, 7406–7411 (1998).

    Article  CAS  PubMed  Google Scholar 

  14. Hollien, J. & Marqusee, S. Proc. Natl. Acad. Sci. USA 96, 13674–13678 (1999).

    Article  CAS  PubMed  Google Scholar 

  15. D'Amico, S., Marx, J.-C., Gerday, C. & Feller, G. J. Mol. Biol. 278, 7891–7896 (2003).

    CAS  Google Scholar 

  16. Hernandez, G., Jenney, F.E., Adams, M.W.W. & LeMaster, D.M. Proc. Natl. Acad. Sci. USA 97, 3166–3170 (2000).

    Article  CAS  PubMed  Google Scholar 

  17. Butterwick, J.A. et al. J. Mol. Biol. 339, 855–871 (2004).

    Article  CAS  PubMed  Google Scholar 

  18. Warshel, A. & Parson, W.W. Q. Rev. Biophys. 34, 563–679 (2001).

    Article  CAS  PubMed  Google Scholar 

  19. Palmer, A.G., Kroenke, C.D. & Loria, J.P. Methods Enzymol. 339, 204–238 (2001).

    Article  CAS  PubMed  Google Scholar 

  20. Eisenmesser, E.Z., Bosco, D.A., Akke, M. & Kern, D. Science 295, 1520–1523 (2002).

    Article  CAS  PubMed  Google Scholar 

  21. Akke, M. Curr. Opin. Struct. Biol. 12, 642–647 (2002).

    Article  CAS  PubMed  Google Scholar 

  22. Vasavada, K.V., Kaplan, J.I. & Rao, B.D.N. Biochemistry 23, 961–968 (1984).

    Article  CAS  PubMed  Google Scholar 

  23. Kantor, H.L., Ferretti, J.A. & Balaban, R.S. Biochim. Biophys. Acta 789, 128–135 (1984).

    Article  CAS  PubMed  Google Scholar 

  24. Mendz, G.L., Robinson, G. & Kuchel, P.W. J. Am. Chem. Soc. 108, 169–173 (1986).

    Article  CAS  Google Scholar 

  25. Mulder, F.A.A., Mittermaier, A., Hon, B., Dahlquist, F.W. & Kay, L.E. Nat. Struct. Biol. 8, 932–935 (2001).

    Article  CAS  PubMed  Google Scholar 

  26. Grey, M.J., Wang, C. & Palmer, A.G. J. Am. Chem. Soc. 125, 14324–14335 (2003).

    Article  CAS  PubMed  Google Scholar 

  27. Korzhnev, D.M. et al. Nature 430, 586–590 (2004).

    Article  CAS  PubMed  Google Scholar 

  28. Malmendal, A., Evenäs, J., Forsén, S. & Akke, M. J. Mol. Biol. 293, 883–899 (1999).

    Article  CAS  PubMed  Google Scholar 

  29. Evenäs, J., Malmendal, A. & Akke, M. Structure 9, 185–195 (2001).

    Article  PubMed  Google Scholar 

  30. Volkman, B.F., Lipson, D., Wemmer, D.E. & Kern, D. Science 291, 2429–2433 (2001).

    Article  CAS  PubMed  Google Scholar 

  31. Hass, M.A.S., Thuesen, M.H., Christensen, H.E.M. & Led, J.J. J. Am. Chem. Soc. 126, 753–765 (2004).

    Article  CAS  PubMed  Google Scholar 

  32. Shapiro, Y.E., Sinev, M.A., Sineva, E.V., Tugarinov, V. & Meirovitch, E. Biochemistry 39, 6634–6644 (2000).

    Article  CAS  PubMed  Google Scholar 

  33. Shapiro, Y.E. et al. Biochemistry 41, 6271–6281 (2002).

    Article  CAS  PubMed  Google Scholar 

  34. Kumar, S., Ma, B., Tsai, C.-J., Sinha, N. & Nussinov, R. Prot. Sci. 9, 10–19 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biophysical Chemistry, Lund University, P.O.Box 124, Lund, SE-221 00, Sweden

    Mikael Akke

Authors
  1. Mikael Akke
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Akke, M. Out of hot water. Nat Struct Mol Biol 11, 912–913 (2004). https://doi.org/10.1038/nsmb1004-912

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb1004-912

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing