A second high-affinity binding site for the I-TevI homing endonuclease has been discovered. Surprisingly, the DNA sequence recognized is the protein's own operator; at this site, the endonuclease represses its own transcription instead of cleaving the DNA and inducing intron homing.
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Acknowledgements
We thank T. Skern for comments on the manuscript. Preparation of this News & Views was supported by the Austrian Science Foundation, FWF grant no. Z72.
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Windbichler, N., Schroeder, R. Double duty. Nat Struct Mol Biol 11, 910–911 (2004). https://doi.org/10.1038/nsmb1004-910
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DOI: https://doi.org/10.1038/nsmb1004-910