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Grabbing E2 by the tail

Nature Structural & Molecular Biology volume 11, pages 908–909 (2004)Cite this article

Ubiquitin-like proteins, including NEDD8, regulate a wide range of cellular processes and are mobilized by parallel biochemical pathways. A recent crystal structure explains how the NEDD8-specific E1 enzyme specifically recruits its cognate E2 enzyme by binding to a flexible N-terminal extension.

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Figure 1: Composite model of the APPBP1–UBA3 E1 and its interactions.

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  1. Department of Biochemistry, University of Utah, Salt Lake City, 84132-3201, Utah, USA

    Andrew P VanDemark & Christopher P Hill

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  1. Andrew P VanDemark
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  2. Christopher P Hill
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VanDemark, A., Hill, C. Grabbing E2 by the tail. Nat Struct Mol Biol 11, 908–909 (2004). https://doi.org/10.1038/nsmb1004-908

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