Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The p53 transcriptional synapse: activation on demand

Nature Structural & Molecular Biology volume 16, pages 900–901 (2009)Cite this article

The adequate and on-time response of cellular transcription to internal needs and external stimuli is a delicate task. Is the transcriptional regulator p53 on call to permit rapid activation of its target genes? A new study reports interplay of p53 with a previously unidentified regulator, calcineurin-binding protein 1 (Cabin1), and provides evidence for such a mechanism.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Hypothetical model for Cabin1 regulation of p53 activity on the GADD45A gene.

References

  1. Molchadsky, A. et al. PLoS One 3, e3707 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Espinosa, J.M. Oncogene 27, 4013–4023 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Jang, H., Choi, S.-Y., Cho, E.-J. & Youn, H.-D. Nat. Struct. Mol. Biol. 16, 910–915 (2009).

    Article  CAS  PubMed  Google Scholar 

  4. Devary, Y., Gottlieb, R.A., Lau, L.F. & Karin, M. Mol. Cell. Biol. 11, 2804–2811 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kho, P.S. et al. J. Biol. Chem. 279, 21183–21192 (2004).

    Article  CAS  PubMed  Google Scholar 

  6. Hargreaves, D.C., Horng, T. & Medzhitov, R. Cell 138, 129–145 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Graunke, D.M., Fornace, A.J. Jr . & Pieper, R.O. Nucleic Acids Res. 27, 3881–3890 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Braastad, C.D., Han, Z. & Hendrickson, E.A. J. Biol. Chem. 278, 8261–8268 (2003).

    Article  CAS  PubMed  Google Scholar 

  9. Xiao, G., White, D. & Bargonetti, J. Oncogene 16, 1171–1181 (1998).

    Article  CAS  PubMed  Google Scholar 

  10. Edwards, D.R. & Mahadevan, L.C. EMBO J. 11, 2415–2424 (1992).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Clayton, A.L., Hazzalin, C.A. & Mahadevan, L.C. Mol. Cell 23, 289–296 (2006).

    Article  CAS  PubMed  Google Scholar 

  12. Edmunds, J.W. & Mahadevan, L.C. Science 313, 449–451 (2006).

    Article  CAS  PubMed  Google Scholar 

  13. Malecka, K.A., Ho, W.C. & Marmorstein, R. Oncogene 28, 325–333 (2009).

    Article  CAS  PubMed  Google Scholar 

  14. Kaeser, M.D. & Iggo, R.D. Proc. Natl. Acad. Sci. USA 99, 95–100 (2002).

    Article  CAS  PubMed  Google Scholar 

  15. Marenduzzo, D., Faro-Trindade, I. & Cook, P.R. Trends Genet. 23, 126–133 (2007).

    Article  CAS  PubMed  Google Scholar 

  16. An, W., Kim, J. & Roeder, R.G. Cell 117, 735–748 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Genrich V. Tolstonog and Wolfgang Deppert are at the Heinrich-Pette-Institute for Experimental Virology and Immunology, Martinistr. 52, D-20251 Hamburg, Germany.,

    Genrich V Tolstonog & Wolfgang Deppert

Authors
  1. Genrich V Tolstonog
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wolfgang Deppert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Genrich V Tolstonog or Wolfgang Deppert.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tolstonog, G., Deppert, W. The p53 transcriptional synapse: activation on demand. Nat Struct Mol Biol 16, 900–901 (2009). https://doi.org/10.1038/nsmb0909-900

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0909-900

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing