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The chloride channel's appendix

Nature Structural & Molecular Biology volume 15, pages 781–783 (2008)Cite this article

All CLC proteins transport Cl− across membranes. However, the family includes both Cl− channels and Cl−/H+ antiporters, proteins once thought to operate by dramatically different mechanisms. An apparent evolutionary relic, a proton-transport apparatus in a CLC channel, reveals deep intertwinings between channel and transporter mechanisms.

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Figure 1: Conceptual models of CLC transport.

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Authors and Affiliations

  1. Joseph A. Mindell is in the Membrane Transport Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Building 35, MSC 3701, Bethesda, Maryland 20892. mindellj@ninds.nih.gov,

    Joseph A Mindell

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Mindell, J. The chloride channel's appendix. Nat Struct Mol Biol 15, 781–783 (2008). https://doi.org/10.1038/nsmb0808-781

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