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Getting a grip on O-acetyl-ADP-ribose

Nature Structural & Molecular Biology volume 12, pages 560–561 (2005)Cite this article

Members of the sirtuin protein family link gene silencing and heterochromatin formation to NAD+-dependent histone deacetylation. Two papers now implicate O-acetyl-ADP-ribose, the metabolite produced by this reaction, as a small-molecule effector that binds to heterochromatic proteins.

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Figure 1: Sirtuin activity and heterochromatin.

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Authors and Affiliations

  1. Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, 21205-2185, Maryland, USA

    Kevin G Hoff & Cynthia Wolberger

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  1. Kevin G Hoff
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  2. Cynthia Wolberger
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Hoff, K., Wolberger, C. Getting a grip on O-acetyl-ADP-ribose. Nat Struct Mol Biol 12, 560–561 (2005). https://doi.org/10.1038/nsmb0705-560

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