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It takes more than two to tango: Dishevelled polymerization and Wnt signaling

Nature Structural & Molecular Biology volume 14, pages 463–465 (2007)Cite this article

Wnt signaling has key roles in embryogenesis and oncogenesis, yet several aspects of Wnt signal transduction remain mysterious. Schwarz-Romond et al. demonstrate that the Wnt signaling protein Dishevelled has the surprising ability to form dynamic polymers and present evidence that polymerization is crucial in signaling, perhaps forming an inducible scaffold for further signal transduction.

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Figure 1: Models of Wnt signal transduction.
Figure 2: Formation of DIX domain filaments.

References

  1. Logan, C.Y. & Nusse, R. Annu. Rev. Cell Dev. Biol. 20, 781–810 (2004).

    Article  CAS  Google Scholar 

  2. Clevers, H. Cell 127, 469–480 (2006).

    Article  CAS  Google Scholar 

  3. Wharton, K.A. Jr. Dev. Biol. 253, 1–17 (2003).

    Article  CAS  Google Scholar 

  4. Klingensmith, J., Nusse, R. & Perrimon, N. Genes Dev. 8, 118–130 (1994).

    Article  CAS  Google Scholar 

  5. Theisen, H. et al. Development 120, 347–360 (1994).

    CAS  PubMed  Google Scholar 

  6. Yanagawa, S., van Leeuwen, F., Wodarz, A., Klingensmith, J. & Nusse, R. Genes Dev. 9, 1087–1097 (1995).

    Article  CAS  Google Scholar 

  7. Yang-Snyder, J., Miller, J.R., Brown, J.D., Lai, C.J. & Moon, R.T. Curr. Biol. 6, 1302–1306 (1996).

    Article  CAS  Google Scholar 

  8. Capelluto, D.G. et al. Nature 419, 726–729 (2002).

    Article  CAS  Google Scholar 

  9. Schwarz-Romond, T., Merrifield, C., Nichols, B.J. & Bienz, M. J. Cell Sci. 118, 5269–5277 (2005).

    Article  CAS  Google Scholar 

  10. Smalley, M.J. et al. J. Cell Sci. 118, 5279–5289 (2005).

    Article  CAS  Google Scholar 

  11. Axelrod, J.D., Miller, J.R., Shulman, J.M., Moon, R.T. & Perrimon, N. Genes Dev. 12, 2610–2622 (1998).

    Article  CAS  Google Scholar 

  12. Schwarz-Romond, T., Metcalfe, C. & Bienz, M. J. Cell Sci. (in the press).

  13. Schwarz-Romond, T. et al. Nat. Struct. Mol. Biol. 14, 484–492 (2007).

    Article  CAS  Google Scholar 

  14. Fagotto, F. et al. J. Cell Biol. 145, 741–756 (1999).

    Article  CAS  Google Scholar 

  15. Kishida, S. et al. Mol. Cell. Biol. 19, 4414–4422 (1999).

    Article  CAS  Google Scholar 

  16. Wong, H.C. et al. Mol. Cell 12, 1251–1260 (2003).

    Article  CAS  Google Scholar 

  17. Cliffe, A., Hamada, F. & Bienz, M. Curr. Biol. 13, 960–966 (2003).

    Article  CAS  Google Scholar 

  18. Tamai, K. et al. Mol. Cell 13, 149–156 (2004).

    Article  CAS  Google Scholar 

  19. Mao, J. et al. Mol. Cell 7, 801–809 (2001).

    Article  CAS  Google Scholar 

  20. Tolwinski, N.S. et al. Dev. Cell 4, 407–418 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Kevin C. Slep and Mark Peifer are in the Department of Biology, David M. Roberts, and David M. Roberts and Mark Peifer are at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB#3280, Coker Hall, Chapel Hill, North Carolina 27599–3280, USA. peifer@unc.edu,

    David M Roberts, Kevin C Slep & Mark Peifer

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  1. David M Roberts
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  2. Kevin C Slep
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Roberts, D., Slep, K. & Peifer, M. It takes more than two to tango: Dishevelled polymerization and Wnt signaling. Nat Struct Mol Biol 14, 463–465 (2007). https://doi.org/10.1038/nsmb0607-463

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