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Modifications target spliceosome dynamics

Nature Structural & Molecular Biology volume 15, pages 426–428 (2008)Cite this article

The splicing pathway is dominated by ATP-dependent RNA rearrangements promoted by DEAD-box helicases. Post-translational modifications have now been implicated in the regulation of two DEAD-box proteins that are required for catalytic activation of the spliceosome.

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Figure 1: The steps in spliceosome assembly, catalysis and spliceosome disassembly are shown schematically.
Figure 2: ATP-dependent exchange of RNA pairing partners is mediated by DEAD-box helicases.
Figure 3: Post-translational modifications target spliceosomal dynamics.

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Acknowledgements

We thank T. Kress and R. Holmes for helpful discussions.

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Authors and Affiliations

  1. Corina Maeder and Christine Guthrie are in the Department of Biochemistry and Biophysics, Genentech Hall N374, University of California San Francisco, 600 16th Street, San Francisco, California 94143-2200, USA. guthrie@biochem.ucsf.edu.,

    Corina Maeder & Christine Guthrie

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  1. Corina Maeder
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  2. Christine Guthrie
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Maeder, C., Guthrie, C. Modifications target spliceosome dynamics. Nat Struct Mol Biol 15, 426–428 (2008). https://doi.org/10.1038/nsmb0508-426

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