One of many consequences of heat shock is a general and profound inhibition of pre-mRNA splicing. In mammalian cells, this inhibition is mediated by a specific member of the SR protein family of splicing factors, which becomes a splicing repressor upon heat-triggered dephosphorylation.
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Nilsen, T. Too hot to splice. Nat Struct Mol Biol 11, 208–209 (2004). https://doi.org/10.1038/nsmb0304-208
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DOI: https://doi.org/10.1038/nsmb0304-208
