Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Hasty decisions on the ribosome

The ribosome must be very selective for aminoacyl-tRNAs while maintaining a rapid rate of protein synthesis. A recent kinetic study reveals how it is able to make quick and accurate decisions to maintain high fidelity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Kinetic scheme of decoding.

References

  1. Gromadski, K. & Rodnina, M. Mol. Cell 13, 191–200 (2004).

    Article  CAS  Google Scholar 

  2. Rodnina, M.V., Fricke, R. & Wintermeyer, W. Biochemistry 33, 12267–12275 (1994).

    Article  CAS  Google Scholar 

  3. Rodnina, M.V., Fricke, R., Kuhn, L. & Wintermeyer, W. EMBO J. 14, 2613–2619 (1995).

    Article  CAS  Google Scholar 

  4. Rodnina, M.V., Pape, T., Fricke, R. & Wintermeyer, W. Biochem. Cell Biol. 73, 1221–1227 (1995).

    Article  CAS  Google Scholar 

  5. Rodnina, M.V., Pape, T., Fricke, R., Kuhn, L. & Wintermeyer, W. J. Biol. Chem. 271, 646–652 (1996).

    Article  CAS  Google Scholar 

  6. Rodnina, M.V., Savelsbergh, A., Katunin, V.I. & Wintermeyer, W. Nature 385, 37–41 (1997).

    Article  CAS  Google Scholar 

  7. Pape, T., Wintermeyer, W. & Rodnina, M.V. EMBO J. 17, 7490–7497 (1998).

    Article  CAS  Google Scholar 

  8. Pape, T., Wintermeyer, W. & Rodnina, M. EMBO J. 18, 3800–3807 (1999).

    Article  CAS  Google Scholar 

  9. Bouadloun, F., Donner, D. & Kurland, C.G. EMBO J. 2, 1351–1356 (1983).

    Article  CAS  Google Scholar 

  10. Khazaie, K., Buchanan, J.H. & Rosenberger, R.F. Eur. J. Biochem. 144, 485–489 (1984).

    Article  CAS  Google Scholar 

  11. Parker, J. & Holtz, G. Biochem. Biophys. Res. Commun. 121, 487–492 (1984).

    Article  CAS  Google Scholar 

  12. Precup, J., Ulrich, A.K., Roopnarine, O. & Parker, J. Mol. Gen. Genet. 218, 397–401 (1989).

    Article  CAS  Google Scholar 

  13. Rice, J.B., Libby, R.T. & Reeve, J.N. J. Biol. Chem. 259, 6505–6510 (1984).

    CAS  PubMed  Google Scholar 

  14. Ban, N., Nissen, P., Hansen, J., Moore, P.B. & Steitz, T.A. Science 289, 905–920 (2000).

    Article  CAS  Google Scholar 

  15. Nissen, P., Hansen, J., Ban, N., Moore, P.B. & Steitz, T.A. Science 289, 920–930 (2000).

    Article  CAS  Google Scholar 

  16. Yusupov, M.M. et al. Science 292, 883–896 (2001).

    Article  CAS  Google Scholar 

  17. Pyle, A.M. J. Biol. Inorg. Chem. 7, 679–690 (2002).

    Article  CAS  Google Scholar 

  18. Fedor, M.J. Curr. Opin. Struct. Biol. 12, 289–295 (2002).

    Article  CAS  Google Scholar 

  19. Ogle, J.M., Murphy, F.V., Tarry, M.J. & Ramakrishnan, V. Cell 111, 721–732 (2002).

    Article  CAS  Google Scholar 

  20. Valle, M. et al. EMBO J. 21, 3557–3567 (2002).

    Article  CAS  Google Scholar 

  21. Stark, H. et al. Nat. Struct. Biol. 9, 849–854 (2002).

    CAS  PubMed  Google Scholar 

  22. Smith, D. & Yarus, M. J. Mol. Biol. 206, 503–511 (1989).

    Article  CAS  Google Scholar 

  23. Smith, D. & Yarus, M. J. Mol. Biol. 206, 489–501 (1989).

    Article  CAS  Google Scholar 

  24. Patel, S.S., Wong, I. & Johnson, K.A. Biochemistry 30, 511–525 (1991).

    Article  CAS  Google Scholar 

  25. Wong, I., Patel, S.S. & Johnson, K.A. Biochemistry 30, 526–537 (1991).

    Article  CAS  Google Scholar 

  26. Reddy, M.K., Weitzel, S.E. & von Hippel, P.H. J. Biol. Chem. 267, 14157–14166 (1992).

    CAS  PubMed  Google Scholar 

  27. Khare, V. & Eckert, K.A. Mutat. Res. 510, 45–54 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sherlin, L., Uhlenbeck, O. Hasty decisions on the ribosome. Nat Struct Mol Biol 11, 206–208 (2004). https://doi.org/10.1038/nsmb0304-206

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0304-206

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing