The ribosome must be very selective for aminoacyl-tRNAs while maintaining a rapid rate of protein synthesis. A recent kinetic study reveals how it is able to make quick and accurate decisions to maintain high fidelity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gromadski, K. & Rodnina, M. Mol. Cell 13, 191–200 (2004).
Rodnina, M.V., Fricke, R. & Wintermeyer, W. Biochemistry 33, 12267–12275 (1994).
Rodnina, M.V., Fricke, R., Kuhn, L. & Wintermeyer, W. EMBO J. 14, 2613–2619 (1995).
Rodnina, M.V., Pape, T., Fricke, R. & Wintermeyer, W. Biochem. Cell Biol. 73, 1221–1227 (1995).
Rodnina, M.V., Pape, T., Fricke, R., Kuhn, L. & Wintermeyer, W. J. Biol. Chem. 271, 646–652 (1996).
Rodnina, M.V., Savelsbergh, A., Katunin, V.I. & Wintermeyer, W. Nature 385, 37–41 (1997).
Pape, T., Wintermeyer, W. & Rodnina, M.V. EMBO J. 17, 7490–7497 (1998).
Pape, T., Wintermeyer, W. & Rodnina, M. EMBO J. 18, 3800–3807 (1999).
Bouadloun, F., Donner, D. & Kurland, C.G. EMBO J. 2, 1351–1356 (1983).
Khazaie, K., Buchanan, J.H. & Rosenberger, R.F. Eur. J. Biochem. 144, 485–489 (1984).
Parker, J. & Holtz, G. Biochem. Biophys. Res. Commun. 121, 487–492 (1984).
Precup, J., Ulrich, A.K., Roopnarine, O. & Parker, J. Mol. Gen. Genet. 218, 397–401 (1989).
Rice, J.B., Libby, R.T. & Reeve, J.N. J. Biol. Chem. 259, 6505–6510 (1984).
Ban, N., Nissen, P., Hansen, J., Moore, P.B. & Steitz, T.A. Science 289, 905–920 (2000).
Nissen, P., Hansen, J., Ban, N., Moore, P.B. & Steitz, T.A. Science 289, 920–930 (2000).
Yusupov, M.M. et al. Science 292, 883–896 (2001).
Pyle, A.M. J. Biol. Inorg. Chem. 7, 679–690 (2002).
Fedor, M.J. Curr. Opin. Struct. Biol. 12, 289–295 (2002).
Ogle, J.M., Murphy, F.V., Tarry, M.J. & Ramakrishnan, V. Cell 111, 721–732 (2002).
Valle, M. et al. EMBO J. 21, 3557–3567 (2002).
Stark, H. et al. Nat. Struct. Biol. 9, 849–854 (2002).
Smith, D. & Yarus, M. J. Mol. Biol. 206, 503–511 (1989).
Smith, D. & Yarus, M. J. Mol. Biol. 206, 489–501 (1989).
Patel, S.S., Wong, I. & Johnson, K.A. Biochemistry 30, 511–525 (1991).
Wong, I., Patel, S.S. & Johnson, K.A. Biochemistry 30, 526–537 (1991).
Reddy, M.K., Weitzel, S.E. & von Hippel, P.H. J. Biol. Chem. 267, 14157–14166 (1992).
Khare, V. & Eckert, K.A. Mutat. Res. 510, 45–54 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sherlin, L., Uhlenbeck, O. Hasty decisions on the ribosome. Nat Struct Mol Biol 11, 206–208 (2004). https://doi.org/10.1038/nsmb0304-206
Issue Date:
DOI: https://doi.org/10.1038/nsmb0304-206