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The flow of gene expression

Gene expression is a highly interconnected multistep process. A recent meeting in Iguazu Falls, Argentina, highlighted the need to uncover both the molecular details of each single step as well as the mechanisms of coordination among processes in order to fully understand the expression of genes.

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References

  1. Maniatis, T. & Reed, R. Nature 416, 499–506 (2002).

    Article  CAS  Google Scholar 

  2. Espinosa, J.M., Verdun, R.E. & Emerson, B.M. Mol. Cell 12, 1015–1027 (2003).

    Article  CAS  Google Scholar 

  3. Ladurner, A.G., Inouye, C., Jain, R. & Tjian, R. Mol. Cell 11, 365–376 (2003).

    Article  CAS  Google Scholar 

  4. Lusic, M., Marcello, A., Cereseto, A. & Giacca, M. EMBO J. 22, 6550–6561 (2003).

    Article  CAS  Google Scholar 

  5. Cartegni, L. & Krainer, A.R. Nat. Genet. 30, 377–384 (2002).

    Article  CAS  Google Scholar 

  6. Pagani, F. et al. Hum. Mol. Genet. 12, 1111–1120 (2003).

    Article  CAS  Google Scholar 

  7. Baralle, M. et al. J. Med. Genet. 40, 220–222 (2003).

    Article  CAS  Google Scholar 

  8. de la Mata, M. et al. Mol. Cell 12, 525–532 (2003).

    Article  CAS  Google Scholar 

  9. Morillon, A., O'Sullivan, J., Azad, A., Proudfoot, N. & Mellor, J. Science 300, 492–495 (2003).

    Article  CAS  Google Scholar 

  10. Alen, C. et al. Mol. Cell 10, 1441–1452 (2002).

    Article  CAS  Google Scholar 

  11. Papa, F.R., Zhang, C., Shokat, K. & Walter, P. Science 302, 1533–1537 (2003).

    Article  CAS  Google Scholar 

  12. Wollerton, M.C., Gooding, C., Wagner, E.J., Garcia-Blanco, M.A. & Smith, C.W. Mol. Cell 13, 91–100 (2004).

    Article  CAS  Google Scholar 

  13. Lewis, B.P., Green, R.E. & Brenner, S.E. Proc. Natl. Acad. Sci. USA 100, 189–192 (2003).

    Article  CAS  Google Scholar 

  14. Ishigaki, Y., Li, X., Serin, G. & Maquat, L.E. Cell 106, 607–617 (2001).

    Article  CAS  Google Scholar 

  15. Lejeune, F., Li, X. & Maquat, L.E. Mol. Cell 12, 675–687 (2003).

    Article  CAS  Google Scholar 

  16. Huang, Y., Gattoni, R., Stevenin, J. & Steitz, J.A. Mol. Cell 11, 837–843 (2003).

    Article  CAS  Google Scholar 

  17. Hirose, T., Shu, M.D. & Steitz, J.A. Mol. Cell 12, 113–123 (2003).

    Article  CAS  Google Scholar 

  18. Nguyen, V.T., Kiss, T., Michels, A.A. & Bensaude, O. Nature 414, 322–325 (2001).

    Article  CAS  Google Scholar 

  19. Kwek, K.Y. et al. Nat. Struct. Biol. 9, 800–805 (2002).

    CAS  PubMed  Google Scholar 

  20. Lund, E., Guttinger, S., Calado, A., Dahlberg, J.E. & Kutay, U. Science 303, 95–98 (2004).

    Article  CAS  Google Scholar 

  21. Marcello, A. et al. EMBO J. 22, 2156–2166 (2003).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

I thank D. Bentley for refreshing my memory and for constructive comments on the manuscript. T.M. is a fellow of the Keith R. Porter Endowment for Cell Biology.

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Misteli, T. The flow of gene expression. Nat Struct Mol Biol 11, 202–205 (2004). https://doi.org/10.1038/nsmb0304-202

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