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Understanding how the replisome works

Nature Structural & Molecular Biology volume 15, pages 125–127 (2008)Cite this article

Recent papers shed insight into the architecture and dynamics of the components of the bacterial replisome.

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Figure 1: General architecture of the helicase–primase complex.

Kim Caesar

References

  1. Bailey, S., Eliason, W.K. & Steitz, T.A. Science 318, 459–463 (2007).

    Article  CAS  Google Scholar 

  2. Wang, G. et al. Nat. Struct. Mol. Biol. 15, 94–100 (2008).

    Article  CAS  Google Scholar 

  3. Corn, J.E., Pelton, J.G. & Berger, J.M. Nat. Struct. Mol. Biol. 15, 163–169 (2008).

    Article  CAS  Google Scholar 

  4. Tanner, N.A. et al. Nat. Struct. Mol. Biol. 15, 170–176 (2008).

    Article  CAS  Google Scholar 

  5. Wu, C.A., Zechner, E.L. & Marians, K.J.J. Biol. Chem. 267, 4030–4044 (1992).

    CAS  Google Scholar 

  6. Tougu, K., Peng, H. & Marians, K.J.J. Biol. Chem. 269, 4675–4682 (1994).

    CAS  Google Scholar 

  7. Tougu, K. & Marians, K.J.J. Biol. Chem. 271, 21398–21405 (1996).

    Article  CAS  Google Scholar 

  8. Yang, J., Nelson, S.W. & Benkovic, S.J. Mol. Cell 21, 153–164 (2006).

    Article  CAS  Google Scholar 

  9. Nunez-Ramirez, R. et al. J. Mol. Biol. 357, 1063–1076 (2006).

    Article  CAS  Google Scholar 

  10. LeBowitz, J.H. & McMacken, R.J. Biol. Chem. 261, 4738–4748 (1986).

    CAS  Google Scholar 

  11. Corn, J.E., Pease, P.J., Hura, G.L. & Berger, J.M. Mol. Cell 20, 391–401 (2005).

    Article  CAS  Google Scholar 

  12. Zechner, E.L., Wu, C.A. & Marians, K.J.J. Biol. Chem. 267, 4045–4053 (1992).

    CAS  Google Scholar 

  13. Yuzhakov, A., Kelman, Z. & O'Donnell, M. Cell 96, 153–163 (1999).

    Article  CAS  Google Scholar 

  14. Keck, J.L., Roche, D.D., Lynch, A.S. & Berger, J.M. Science 287, 2482–2486 (2000).

    Article  CAS  Google Scholar 

  15. VanLoock, M.S., Chen, Y.J., Yu, X., Patel, S.S. & Egelman, E.H.J. Mol. Biol. 311, 951–956 (2001).

    Article  CAS  Google Scholar 

  16. Khopde, S., Biswas, E.E. & Biswas, S.B. Biochemistry 41, 14820–14830 (2002).

    Article  CAS  Google Scholar 

  17. Li, X. & Marians, K.J.J. Biol. Chem. 275, 34757–34765 (2000).

    Article  CAS  Google Scholar 

  18. Mok, M. & Marians, K.J.J. Biol. Chem. 262, 16644–16654 (1987).

    CAS  Google Scholar 

  19. Lee, J.B. et al. Nature 439, 621–624 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Kenneth J. Marians is the chair of the Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA. kmarians@sloankettering.edu,

    Kenneth J Marians

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  1. Kenneth J Marians
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Marians, K. Understanding how the replisome works. Nat Struct Mol Biol 15, 125–127 (2008). https://doi.org/10.1038/nsmb0208-125

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