Polyglutamine (polyGln) expansions induce protein misfolding and aggregation into fibrillar deposits, which are believed to underlie forms of neurodegeneration through a mechanism involving gain of toxic function. Polyalalanine expansions are now shown to differ from polyGln in kinetics of aggregation, morphology of aggregates and mechanism of toxicity.
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References
Faux, N.G. et al. Genome Res. 15, 537–551 (2005).
Polling, S. et al. Nat. Struct. Mol. Biol. 22, 1008–1015 (2015).
Dyson, H.J. Q. Rev. Biophys. 44, 467–518 (2011).
Tran, H.T., Mao, A. & Pappu, R.V. J. Am. Chem. Soc. 130, 7380–7392 (2008).
Turoverov, K.K., Kuznetsova, I.M. & Uversky, V.N. Prog. Biophys. Mol. Biol. 102, 73–84 (2010).
Dunker, A.K. et al. J. Mol. Graph. Model. 19, 26–59 (2001).
Gatchel, J.R. & Zoghbi, H.Y. Nat. Rev. Genet. 6, 743–755 (2005).
Bauer, P.O. & Nukina, N. J. Neurochem. 110, 1737–1765 (2009).
Walters, R.H. & Murphy, R.M. J. Mol. Biol. 393, 978–992 (2009).
Crick, S.L., Ruff, K.M., Garai, K., Frieden, C. & Pappu, R.V. Proc. Natl. Acad. Sci. USA 110, 20075–20080 (2013).
Vitalis, A., Lyle, N. & Pappu, R.V. Biophys. J. 97, 303–311 (2009).
Chen, S., Ferrone, F.A. & Wetzel, R. Proc. Natl. Acad. Sci. USA 99, 11884–11889 (2002).
Landrum, E. & Wetzel, R. J. Biol. Chem. 289, 10254–10260 (2014).
Brown, L.Y. & Brown, S.A. Trends Genet. 20, 51–58 (2004).
Messaed, C. & Rouleau, G.A. Neurobiol. Dis. 34, 397–405 (2009).
Blondelle, S.E., Forood, B., Houghten, R.A. & Pérez-Payá, E. Biochemistry 36, 8393–8400 (1997).
Shinchuk, L.M. et al. Proteins 61, 579–589 (2005).
Giri, K., Bhattacharyya, N.P. & Basak, S. Biophys. J. 92, 293–302 (2007).
Bernacki, J.P. & Murphy, R.M. Biochemistry 50, 9200–9211 (2011).
Scheuermann, T. et al. Protein Sci. 12, 2685–2692 (2003).
Winter, R., Kühn, U., Hause, G. & Schwarz, E. J. Biol. Chem. 287, 22662–22671 (2012).
Halfmann, R. et al. Mol. Cell 43, 72–84 (2011).
Lu, X. & Murphy, R.M. Biochemistry 54, 4784–4794 (2015).
Newby, G.A. & Lindquist, S. Trends Cell Biol. 23, 251–259 (2013).
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Murphy, R. Q&A: repeat-containing proteins. Nat Struct Mol Biol 22, 943–945 (2015). https://doi.org/10.1038/nsmb.3135
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DOI: https://doi.org/10.1038/nsmb.3135