Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

A leucine-rich repeat variant with a novel repetitive protein structural motif

The structure of the leucine-rich repeat variant protein reveals a novel fold consisting of alternating α- and 310-helices arranged in a right-handed superhelix that follows an N-terminal 4Fe:4S cluster-containing domain.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kobe, B. & Deisenhofer, J. Trends Biochem. Sci. 19, 415–421 (1994).

    Article  CAS  Google Scholar 

  2. Kobe, B. & Deisenhofer, J. Curr. Opin. Struct. Biol. 5, 409–416 (1995).

    Article  CAS  Google Scholar 

  3. Kobe, B. & Deisenhofer, J. Nature 366, 751–756 (1993).

    Article  CAS  Google Scholar 

  4. Jacobson, M.R. et al. J. Bacteriol. 171, 1017–1027 (1989).

    Article  CAS  Google Scholar 

  5. Hutchinson, E.G. & Thornton, J.M. Prot. Sci. 5, 212–220 (1996).

    Article  CAS  Google Scholar 

  6. Kabsch, W. Acta Crystallogr. A32, 922–923 (1976).

    Article  Google Scholar 

  7. Cox, J.M. J. Mol. Biol. 28, 151–156. (1967).

    Article  CAS  Google Scholar 

  8. Rouault, T.A. & Klausner, R.D. Trends Biochem. Sci. 21, 174–177 (1996).

    Article  CAS  Google Scholar 

  9. Barlow, D.J. & Thornton, J.M. J. Mol. Biol. 201, 601–619 (1988).

    Article  CAS  Google Scholar 

  10. Toniolo, C. & Benedetti, E. Trends Biochem. Sci. 16, 350–353 (1991).

    Article  CAS  Google Scholar 

  11. Millhauser, G.L. Biochemistry 34, 3873–3877 (1995).

    Article  CAS  Google Scholar 

  12. Miick, S.M., Martinez, G.V., Fiori, W.R., Todd, A.P. & Millhauser, G.L. Nature 359, 653–655 (1992).

    Article  CAS  Google Scholar 

  13. Peters, J.W., Fisher, K. & Dean, D.R. J. Biol. Chem. 269, 28076–28083 (1994).

    CAS  PubMed  Google Scholar 

  14. Georgiadis, M.M. et al. Science 257, 1653–1659 (1992).

    Article  CAS  Google Scholar 

  15. Stowell, M.H.B. et al. J. Appl. Crystallogr. 29, 608–613 (1996).

    Article  CAS  Google Scholar 

  16. Otwinowski, Z. in Data Collection and Processing (eds. Sawyer, L, Issacs, N. & Bailey, S.) 56–62 (SERC Daresbury Laboratory, UK, 1993).

    Google Scholar 

  17. Bailey, S. Acta Crystallogr. D50, 760–763 (1994).

    CAS  Google Scholar 

  18. Otwinowski, Z. in Isomorphous Replacement and Anomalous Scattering (eds W. Wolf, P. Evans & A. Leslie) 80–86 (SERC Daresbury Laboratory, UK, 1991).

    Google Scholar 

  19. Furey, W. & Swaminathan, S. in Meth. Enzymol. (eds C. Carter & R. Sweet) in the press (Academic Press, Orlando, 1996).

    Google Scholar 

  20. Abrahams, J.P. & Leslie, A. Acta Crystallogr. D52, 30–42 (1996).

    CAS  Google Scholar 

  21. Jones, T.A., Zhou, J.Y., Cowan, S.W. & Kjeldgaard, M. Acta Crystallogr. A47, 110–119 (1991).

    Article  CAS  Google Scholar 

  22. Brünger, A.T., Kuriyan, J. & Karplus, M. Science 235, 458–460 (1987).

    Article  Google Scholar 

  23. Engh, R.A. & Huber, R. Acta Crystallogr. A47, 392–400 (1991).

    Article  CAS  Google Scholar 

  24. Read, R.J. Acta Crystallogr. A42, 140–149 (1986).

    Article  CAS  Google Scholar 

  25. Laskowski, R.A., McArthur, M.W., Moss, D.S. & Thornton, J.M. J. Appl. Crystallogr. 26, 283–291 (1993).

    Article  CAS  Google Scholar 

  26. Kraulis, P.J. J. Appl. Crystallogr. 24, 946–950 (1991).

    Article  Google Scholar 

  27. Bacon, D. & Anderson, W.F. J. Mol. Graphics 6, 219–220 (1988).

    Article  Google Scholar 

  28. Merritt, E.A. & Murphy, M.E.P. Acta Crystallogr. D50, 869–873 (1994).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Douglas C. Rees.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Peters, J., Stowell, M. & Rees, D. A leucine-rich repeat variant with a novel repetitive protein structural motif. Nat Struct Mol Biol 3, 991–994 (1996). https://doi.org/10.1038/nsb1296-991

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb1296-991

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing