NMR structure of an HIV-1 Rev peotide complexed with either the Rev binding elements or an RNA aptamer show that the helical peotide inserts into a widened major groove. However, significant local differences are observed.
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Ellington, A., Leclerc, F. & Cedergren, R. An RNA groove. Nat Struct Mol Biol 3, 981–984 (1996). https://doi.org/10.1038/nsb1296-981
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DOI: https://doi.org/10.1038/nsb1296-981