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The structure of chain-linked DNA as a possible model for the transcription bubble

Nature Structural Biology volume 2, pages 1060–1061 (1995)Cite this article

An antiparallel DNA decanucleotide displays an unusual crystal structure in which each molecule is linked to a neighbour by base pairs between intertwined, looped strands. The structure suggests a model for the transcription bubble.

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References

  1. Berman, H.M. et al. Biophys. J. 63, 751–759 (1992).

    Article  CAS  Google Scholar 

  2. Joshua-Tor, L. et al. J. molec. Biol. 225, 397–431 (1992).

    Article  CAS  Google Scholar 

  3. Spink, N., Nunn, C.M., Vojtechovsky, J., Berman, H.M. & Neidle, S. Proc. natn. Acad. Sci. U.S.A. in the press.

  4. Klimasauskas, S., Kumar, S., Roberts, R.J. & Cheng, X. Cell 76, 357–369 (1994).

    Article  CAS  Google Scholar 

  5. Lewin, B. Genes V, 846–849 (Oxford University Press; 1995).

    Google Scholar 

  6. Daube, S.S. & von Hippel, P.H. Science 258, 1320–1324 (1992).

    Article  CAS  Google Scholar 

  7. Sousa, R., Chung, Y.J., Rose, J.P. & Wang, B.-C. Nature 364, 593–599 (1993).

    Article  CAS  Google Scholar 

  8. Rice, G.A., Kane, C.M. & Chamberlain, M.J. Proc. natn. Acad. Sci. U.S.A. 88, 4245–4249 1991.

    Article  CAS  Google Scholar 

  9. Egli, M., Usman, N. & Rich, A. Biochemistry 32, 3221–3237 (1993).

    Article  CAS  Google Scholar 

  10. Navaza, J. Acta Crystallogr. A 50, 157–163 (1994).

    Article  Google Scholar 

  11. Brünger, A.T., Kuriyan, J. & Karplus, M. Science 235, 458–460 1987.

    Article  Google Scholar 

  12. Sheldrick, G.M. SHELX-93, a program for crystal structure refinement (University of Göttingen, Germany, 1993).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Cancer Research Campaign Biomolecular Structure Unit, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK

    Christine M. Nunn & Stephen Neidle

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  1. Christine M. Nunn
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  2. Stephen Neidle
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Nunn, C., Neidle, S. The structure of chain-linked DNA as a possible model for the transcription bubble. Nat Struct Mol Biol 2, 1060–1061 (1995). https://doi.org/10.1038/nsb1295-1060

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