Proteins are the dogmatic workhorses of genetic regulation, able to both sense the presence of small molecules and control gene expression levels. Two recent studies have now shown that RNA molecules can also serve as the 'sensor' components of genetic regulatory circuits.
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References
Hermann, T. & Patel, D.J. Science 287, 820–825 (2000).
Hamaguchi, N., Ellington, A. & Stanton, M. Anal. Biochem. 294, 126–131 (2001).
Hesselberth, J., Robertson, M.P., Jhaveri, S. & Ellington, A.D. J. Biotechnol. 74, 15–25 (2000).
Stojanovic, M.N. & Landry, D.W. J. Am. Chem. Soc. 124, 9678–9679 (2002).
Yamamoto, R., Baba, T. & Kumar, P.K. Genes Cells 5, 389–396 (2000).
Robertson, M.P. & Ellington, A.D. Nature Biotechnol. 19, 650–655 (2001).
Soukup, G.A. & Breaker, R.R. Curr. Opin. Struct. Biol. 10, 318–325 (2000).
Seetharaman, S., Zivarts, M., Sudarsan, N. & Breaker, R.R. Nature Biotechnol. 19, 336–341 (2001).
Wang, D.Y. & Sen, D. Comb. Chem. High Throughput Screen. 5, 301–312 (2002).
Winkler, W., Nahvi, A. & Breaker, R.R. Nature 419, 952–956 (2002).
Miranda-Rios, J., Navarro, M. & Soberon, M. Proc. Natl. Acad. Sci. USA 98, 9736–9741 (2001).
Stormo, G.D. & Ji, Y. Proc. Natl. Acad. Sci. USA 98, 9465–9467 (2001).
Nou, X. & Kadner, R.J. Proc. Natl. Acad. Sci. USA 97, 7190–7195 (2000).
Nahvi, A. et al. Chem. Biol. 9, 1043–1049 (2002).
Vitreschak, A.G., Rodionov, D.A., Mironov, A.A. & Gelfand, M.S. Nucleic Acids Res. 30, 3141–3151 (2002).
Gelfand, M.S., Mironov, A.A., Jomantas, J., Kozlov, Y.I. & Perumov, D.A. Trends Genet. 15, 439–442 (1999).
Dennis, C. Nature 418, 122–124 (2002).
Ambros, V. Cell 107, 823–826 (2001).
Wassarman, K.M. Cell 109, 141–144 (2002).
Rivas, E., Klein, R.J., Jones, T.A. & Eddy, S.R. Curr. Biol. 11, 1369–1373 (2001).
Grate, D. & Wilson, C. Bioorg. Med. Chem. 9, 2565–2570 (2001).
Werstuck, G. & Green, M.R. Science 282, 296–298 (1998).
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Hesselberth, J., Ellington, A. A (ribo) switch in the paradigms of genetic regulation. Nat Struct Mol Biol 9, 891–893 (2002). https://doi.org/10.1038/nsb1202-891
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DOI: https://doi.org/10.1038/nsb1202-891