Abstract
The modulation of enzymatic activity by a protein cofactor may be accomplished in several ways, as illustrated by two new structures.
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References
Banner, D.W. et al. Nature 380, 41–46 (1996).
Metz, B.K. et al. J. Am. Coll. Cardiol. 31, 1493– 1498 (1998).
Vanderschueren, S. et al. Circulation 92, 2044– 2049 (1995).
Castellino, F.J. Trends Biochem. Sci. 1–5 ( 1979).
Sakharov, D.V., Lijnen, H.R. & Rijken, D.C. J. Biol. Chem. 271, 27912– 27918 (1996).
Parry, M.A.A. et al. Nature Struct. Biol. 5, 917– 933 (1998).
Renatus, M. et al. EMBO J. 16, 4797–4805 (1997).
Mulichak, A.M., Tulinsky, A. & Ravichandran, K.G. Biochemistry 30, 10576– 10588 (1991).
Wang, X., Lin, X., Loy, J.A., Tang, J. & Zhang, X.C. Science 281, 1662– 1665 (1998).
Rezaie, A.R., Mather, T., Sussman, F. & Esmon, C.T. J .Biol. Chem. 269, 3151–3154 ( 1994).
Kawabata, S., Morita, T., Miyata, T., Iwanaga, S. & Igarashi, H. J. Biol. Chem. 261, 1427-– 1433 (1986).
Vijayalakshmi, J., Padmanabhan, K.P., Mann, K.G. & Tulinsky, A. Pro. Sci. 3, 2254–2271 ( 1994).
Hedstrom, L., Lin, T.-Y. & Fast, W. Biochemistry 35, 4515– 4523 (1996).
Schlott, B., Gührs, K.-H., Hartmann, M., Röcker, A. & Collen, D. J. Biol. Chem. 273, 22346–22350 (1998).
Cederholm-Williams, S.A., Decock, F., Linjen, H.R. & Collen, D. Eur. J. Biochem. 100, 125–132 ( 1979).
Teitel, J.M. & Rosenberg, R.D. J. Clin. Invest. 71, 1383–1391 (1983).
Broze, G.J. Jr., Girard, T.J. & Novotny, W.F. Biochemistry 29, 7539– 7546 (1990).
Rezaie, A.R., He, X. & Esmon, C.T. Biochemistry 37, 693–699 (1998).
Boyle, M.D.P. & Lottenberg, R. Thromb. Haemost. 77, 1–10 (1997).
Coleman, J.L. et al. Cell 89, 1111–1119 (1997).
Sodeinde, O.A. et al. Science 258, 1004– 1007 (1992).
Iwanaga, S., Kawabata, S. & Muta, T. J. Biochem. (Tokyo) 123, 1– 15 (1998).
Rapaport, S.I. & Rao, L.V.M. Arterioscl. Thromb. 12, 1111–1121 ( 1992).
Huang, Q., Neuenschwander, P.F., Rezaie, A.R. & Morrissey, J.H. J. Biol. Chem. 271, 21752–21757 (1996).
Edgington, T.S., Mackman, N., Brand, K. & Ruf, W. Thromb. Haemost. 66, 67–79 (1991).
Higashi, S., Matsumoto, N. & Iwanaga, S. J. Biol. Chem. 271, 26569– 26574 (1996).
Armstrong, S.A., Husten, E.J., Esmon, C.T. & Johnson, A.E. J. Biol. Chem. 265, 6210–6218 (1990).
Krishnaswamy, S. & Betz, A. Biochemistry 36, 12080–12086 (1997).
Dang, Q.D., Guinto, E.R. & Di Cera, E. Nature Biotech. 15, 146– 149 (1997).
Berg, D.T., Wiley, M.R. & Grinnell, B.W. Science 273, 1389– 1391 (1996).
Gerlitz, B. & Grinnell, B.W. J. Biol. Chem. 271 , 22285–22288 (1996).
Skinner R. et al. J. Mol. Biol. 266, 601– 609 (1997).
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Esmon, C., Mather, T. Switching serine protease specificity. Nat Struct Mol Biol 5, 933–937 (1998). https://doi.org/10.1038/2906
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DOI: https://doi.org/10.1038/2906
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