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NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit

Nature Structural Biology volume 2, pages 951–955 (1995)Cite this article

The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.

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Authors and Affiliations

  1. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Alison Fisher & Barry S. Cooperman

  2. Institute for Cancer Research, Philadelphia, Pennsylvania, 19111, USA

    Paul B. Laub

  3. Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Paul B. Laub

Authors
  1. Alison Fisher
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  2. Paul B. Laub
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  3. Barry S. Cooperman
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Fisher, A., Laub, P. & Cooperman, B. NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit. Nat Struct Mol Biol 2, 951–955 (1995). https://doi.org/10.1038/nsb1195-951

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