Crystal structures of target peptide bound Ca2+-calmodulin linker helix mutants with the helix shortened by two or three residues, or replaced by the longer troponin C central helix, show that the major calmodulin-target structure is preserved at the expense of linker conformation.
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Meador, W., George, S., Means, A. et al. X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants. Nat Struct Mol Biol 2, 943–945 (1995). https://doi.org/10.1038/nsb1195-943
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DOI: https://doi.org/10.1038/nsb1195-943
