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Mechanisms of amyloidogenesis

Nature Structural Biology volume 7, pages 824–826 (2000)Cite this article

Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model — nucleated conformational conversion — that invokes oligomeric intermediates for initiation and assembly.

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Figure 1: Putative models for conversion of amyloidogenic polypeptides into amyloid fibrils.

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  1. the Department of Chemistry, Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, 92037, California, USA

    Jeffery W. Kelly

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  1. Jeffery W. Kelly
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Kelly, J. Mechanisms of amyloidogenesis. Nat Struct Mol Biol 7, 824–826 (2000). https://doi.org/10.1038/82815

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