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The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome

Nature Structural Biology volume 4, pages 712–716 (1997)Cite this article

A Corrigendum to this article was published on 01 October 1997

The structure and dynamics of the first KH domain of FMR1 — the protein responsible for fragile X syndrome — reveal that an exposed loop is highly flexible despite containing a GxxG motif that is well conserved throughout the KH family. We suggest that this region provides a putative binding surface for RNA recognition.

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Authors and Affiliations

  1. EMBL, Meyerhofstr. 1, D-69012, Heidelberg, Germany

    Giovanna Musco, Abdelhakim Kharrat, Gunter Stier, Franca Fraternali, Toby J. Gibson & Michael Nilges

  2. IRCOF, Universite de Rouen, 76821, Mont-Saint-Aignan, Cedex, France

    Annalisa Pastore

Authors
  1. Giovanna Musco
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  2. Abdelhakim Kharrat
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  3. Gunter Stier
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  4. Franca Fraternali
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  5. Toby J. Gibson
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  7. Annalisa Pastore
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Correspondence to Giovanna Musco.

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Musco, G., Kharrat, A., Stier, G. et al. The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome. Nat Struct Mol Biol 4, 712–716 (1997). https://doi.org/10.1038/nsb0997-712

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