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Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activity

Nature Structural Biology volume 2, pages 736–739 (1995)Cite this article

Computer modelling of the antithrombin III–heparin–thrombin complex inspired the synthesis of novel glycoconjugates, whose factor Xa and thrombin inhibitory activites can be adjusted in a rational way, leading to anticoagulants with unprecedented characteristics.

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Authors and Affiliations

  1. N.V. Organon, PO Box 20, 5340 BH, Oss, The Netherlands

    Peter D.J. Grootenhuis, Pieter Westerduin, Dick Meuleman & Constant A.A. van Boeckel

  2. Sanofi Recherche, PO Box 1169, 31036, Toulouse, France

    Maurice Petitou

Authors
  1. Peter D.J. Grootenhuis
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  3. Dick Meuleman
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  4. Maurice Petitou
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  5. Constant A.A. van Boeckel
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Grootenhuis, P., Westerduin, P., Meuleman, D. et al. Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activity. Nat Struct Mol Biol 2, 736–739 (1995). https://doi.org/10.1038/nsb0995-736

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