Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins.
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Chen, X., Ramakrishnan, B. & Sundaralingam, M. Crystal structures of B-form DNA–RNA chimers complexed with distamycin. Nat Struct Mol Biol 2, 733–735 (1995). https://doi.org/10.1038/nsb0995-733
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DOI: https://doi.org/10.1038/nsb0995-733
