The structure of two viral 3C cysteine proteinases confirm predictions of a close similarity with serine proteinases and hint at the evolutionary origins of this family of enzymes.
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References
Allaire, M., Chernaia, M.M., Malcolm, B.A., & James, M.N.G. Nature 369, 72–76 (1994).
Matthews, D.A. et al. Cell 77, 1–20 (1994).
Pelham, H.R.B. Eur. J. Biochem. 85, 457–462 (1978).
Argos, P., Kamer, P., Nicklin, M.J.H., & Wimmer, E. Nucl. Acid. Res. 12, 7251–7257 (1984).
Gorbalenya, A.E., Blinov, J.M., & Donchenko, A.P. FEBS Lett. 194, 253–257 (1986).
Bazan, J.F., & Fletterick, R.J. Proc. natn. Acad. Sci. U.S.A. 85, 7872–7876 (1988).
Gorbalenya, A.E., Donchenko, A.P., Blinov, V.M., & Koomin, E.V. FEBS Lett. 243, 103–114 (1989).
Allaire, M., & James, M.N.G. Nature struct. Biol. 1, 505–506 (1994).
Chothia, C., & Lesk, A.M. EMBO J. 5, 823–826 (1986).
Nienaber, V.L., Breddam, K., & Birktoft, J. J. Biochemistry 32, 1146–1147 (1993).
Winkler, F.K., D'Arcy, A., & Hunziker, W. Nature 343, 771–775 (1990).
Brenner, S. Nature 334, 528–532 (1988).
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Carrell, R., Lesk, A. A tale of two proteinases. Nat Struct Mol Biol 1, 492–494 (1994). https://doi.org/10.1038/nsb0894-492
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DOI: https://doi.org/10.1038/nsb0894-492