Recent crystal structures suggest models for how an asymmetric E2/E2-like protein complex synthesizes a polyubiquitin chain that functions in DNA repair and NF-κB activation pathways.
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References
Koepp, D.M., Harper, J.W. & Elledge, S.J. Cell 97, 431– 434 (1999).
Joazeiro, C.A. & Weissman, A.M. Cell 102, 549– 552 (2000).
Hicke, L. Nature Rev. Mol. Cell Biol. 2, 195– 201 (2001).
Rock, K.L. & Goldberg, A.L. Annu. Rev. Immunol. 17, 739– 779 (1999).
Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425– 479 (1998).
Pickart, C.M. Annu. Rev. Biochem. 70, 503– 533 (2001).
Pickart, C.M. Trends Biochem. Sci. 25, 544– 548 (2000).
Hofmann, R.M. & Pickart, C.M. Cell 96, 645– 653 (1999).
Deng, L. et al. Cell 103, 351– 361 (2000).
Spense, J. et al. Cell 102, 67– 76 (2000).
Galan J, & Haguenauer-Tsapis R. EMBO J. 19, 5847– 5854 (1997).
Spense, J., Sadis, S., Haas, A.L. & Finley, D. Mol. Cell. Biol. 15, 1265– 1273 (1995).
Moraes, T.F. et al. Nature Struct. Biol. 8, 669– 673 (2001).
VanDemark, A.P., Hofmann, R.M., Tsui, C., Pickart, C.M. & Wolberger, C.M. Cell 105, 711– 720 (2001).
Zheng, N., Wang, P., Jeffrey & P.D., Pavletich Cell 102, 533– 539 (2000).
Huang, L. et al. Science 286, 1321– 1326 (1999).
Ptak, C. et al. J. Biol. Chem. 269, 26539– 26545 (1994).
Chen, P., Johnson, P., Sommer, T., Jentsch, S. & Hochstrasser, M. Cell 74, 357– 369 (1993)
Sancho, E. et al. Mol. Cell. Biol. 18, 576– 589 (1998).
Xiao, W., Lin, S.L., Broomfield, S., Chow, B.L., & Wei, Y.F. Nucleic Acids Res. 26, 3908– 3914 (1998).
Glover, J.N. & Harrison, S.C., Nature 373, 257– 261 (1995).
Chen, F.E., Huang, D.B., Chen, Y.Q. & Ghosh, G., Nature 391, 410– 413 (1998).
Miura, T., Klaus, W., Gsell, B., Miyamoto, C. & Senn, H. J. Mol. Biol. 290, 213– 228 (1999).
Liu, Q. et al. J. Biol. Chem. 274, 16979– 16987 (1999).
Ulrich, H.D. & Jentsch, S. EMBO J. 19, 3388– 3397 (2000).
Wang, C. et al. Nature, in the press (2001).
Babst, M., Odorizzi, G., Estepa, E.J. & Emr, S.D. Traffic 1, 248– 258 (2000).
VerPlank, L. et al. Proc. Natl. Acad. Sci. U.S.A. 98, 7724– 7729 (2001).
Koonin, E.V. & Abagyan, R.A. Nature Genet. 16, 330– 331 (1997).
Ponting, C.P., Cai, Y.D. & Bork, P. J. Mol. Med. 75, 467– 469 (1997).
Koegl, M. et al. Cell 96, 635– 644 (1999).
Hofmann, K. & Falquet, L. Trends Biochem. Sci. 26, 347– 350 (2001).
Bertollaet, B.L. et al. Nature Struc. Biol. 8, 417– 422 (2001).
Wilkinson, K.D. Semin. Cell Dev. Biol. 11, 141– 148 (2000).
Carson, M. Macromol. Crystallogr. B 277, 493– 505 (1997).
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Chan, NL., Hill, C. Defining polyubiquitin chain topology. Nat Struct Mol Biol 8, 650–652 (2001). https://doi.org/10.1038/90337
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DOI: https://doi.org/10.1038/90337
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