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Computational protein engineering

Nature Structural Biology volume 5, pages 525–527 (1998)Cite this article

Abstract

Recent advances in automated protein design algorithms are leading a resurgence in structure-based design approaches for protein engineering.

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Figure 1: Best fit superposition of 47 simulated annealing structures, showing the backbone and ten core residues of a seven-fold mutant designed variant of the Streptococcal protein G ß1 domain.

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  1. the Department of Biochemistry, Duke University Medical Center, Box 3711, Durham, 27710, North Carolina, USA

    H.W. Hellinga

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  1. H.W. Hellinga
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Correspondence to H.W. Hellinga.

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Hellinga, H. Computational protein engineering. Nat Struct Mol Biol 5, 525–527 (1998). https://doi.org/10.1038/776

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